AGT and renal carcinoma: In the study by Hartmann and al. published in 2019, it was shown, for example, that exposure to angiotensin II lead to GC → T:A transversions in the transgenic lacI genes of Big Blue rats [79], but in most of the aforementioned models induced by carcinogens especially, the pathophysiology underlying renal carcinogenesis would need to be studied more in depth to allow us to better understand, and maybe prevent, renal cancer development.