In the current study, CV-B4 infection had a significant effect on the expression of Gapdh and RpS29, then Actb and Rp14, then Sdha. These genes were affected by either increase and/or decrease of their expression, observed at Day 1 and/or Day 5 from birth, and mainly following CV-B4 inoculation at Day 17G but also following infection at Day 10G. The gene discussed is ACTB; the disease is infection.