It is not just ADAMTS-12 that can be linked to neuropathies, since ADAMTS-1 (as an example) is overexpressed in the frontal cortex of brains of patients with Down’s syndrome, Alzheimer’s disease (AD), and Pick’s disease, and its presence has been suggested as being a good marker of neurodegeneration [87]. Here, ADAMTS1 is linked to early-onset autosomal dominant Alzheimer disease.