Indeed, in a Mexican cohort with biopsy-confirmed PCa, a panel comprising GSTP1me and RASSF1Ame allowed for cancer detection with 73% positive predictive value (PPV) and 59.6% negative predictive value (NPV), increasing to 81% and 66%, respectively, when serum PSA was also considered [179]. The gene discussed is KLK3; the disease is cancer.