Relative to the control (100%), vitamin D at 0.0002, 0.002, 0.02, and 0.2 μM significantly inhibited MMP-1 protein levels to 76%, 69%,77%, and 78% of control (p < 0.05) (Figure 7A); and significantly inhibited MMP-2 protein levels to 65%, 46%,45%, and 33% of control (p < 0.05) (Figure 7A), in melanoma cells. The gene discussed is MMP1; the disease is melanoma.