Indeed, highly metastatic oral cancer-derived s-EVs contained significant levels of HSPs, including HSP90α, HSP90β, TRAP1, HSP110/HSPH1, and HSP70, which were coordinately increased with EGFR and CD326 (also known as an epithelial cell adhesion molecule (EpCAM)) as compared with low metastatic cell lines [52]. Here, HSPH1 is linked to lip and oral cavity carcinoma.