PTGS2 and neoplasm: In addition to the COX2/prostaglandins cascade, other eicosanoids such as LTs and EETs, FAs, fatty acid-binding proteins (FABPs), and sphingolipids, are signaling lipids that induce malignant phenotypes, including EMT, CSC/CIC pool, circulating tumor cells (CTCs), and metastatic dissemination of exosome/ oncosome [157,158,159].