The cysteine proteases include six subfamilies, ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTU), and Machado–Josephin domain proteases (MJDs), while metalloproteases only comprise the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases, that are zinc-dependent metalloproteinases [8]. Here, COPS5 is linked to neoplasm.