ESR1 and melanoma: On the other hand, SNPs rs2234693 (p = 0.035 < 0.038 critical value) and rs827421 (p = 0.018 < 0.019 critical value) in ESR1 had only borderline Benjamini–Hochberg corrected significant genotypic differences between melanoma cases and healthy controls in the GENEVA dataset (Table 4).