In the unadjusted crude regression analyses (model A), only the recessive genetic models showed significant associations with melanoma: the OR of GG v.s. CC + CG reference genotypes in rs1520220/IGF1 was 2.97 (95% CI: 1.35, 7.23, p = 0.010, model likelihood p = 0.006); the OR of AA vs. GG + GA reference genotypes in rs2229765/IGF1R was 0.29 (95% CI: 0.12, 0.62, p = 0.003, model likelihood p = 0.001) (Table 5). This evidence concerns the gene IGF1R and melanoma.