In the family history of melanoma-adjusted recessive models, the OR for rs1520220/IGF1 was 2.79 (95% CI: 1.24, 6.92, p = 0.018) in model C and approximately the same in model D. The OR for rs2229765/IGF1R was 0.25 (95% CI: 0.10, 0.57, p = 0.002) in model C and remained the same in model D. This might be because of the coefficients of family history of melanoma were highly significant in both models C and D for both SNPs and might confound the SNP results. The gene discussed is IGF1; the disease is melanoma.