BIRC5 and colorectal carcinoma: Furthermore, we validated that Obatoclax-induced transcriptional suppression of survivin and resultant apoptosis is likely due to the inhibitory effect of Obatoclax on the hyperactive β-catenin-mediated signaling commonly present in human CRC cells, as evidenced by the abrogation of survivin downregulation and apoptosis induction in Obatoclax-treated CRC cells stably expressing dominant-active β-catenin mutant (Figure 4 and Figure 5).