Thus, PHLPP1 can inactivate Akt to trigger apoptosis and act as a tumour suppressor in multiple cancers.14, 30 Recently, a study showed that PHLPP1 knock‐down alleviated ischaemic injury in aged heart.32 Nevertheless, whether PHLPP1 can play a part in DCM directly has not been characterized. This evidence concerns the gene AKT1 and neoplasm.