In the current study, we observed markedly up‐regulated expression of FBXL7 glioma cells, in accordance with earlier reports.16, 36 Further, FBXL7 expression correlated with the grade of glioma and poor prognosis.15 In vitro functional analysis showed that knock‐down of FBXL7 repressed invasion, proliferation and migration of glioma cell and impeded in vivo growth of glioma xenograft tumour. Here, FBXL7 is linked to glioma.