Cell viability was found to be reduced significantly in U87 and U251 cells stimulated with TMZ when compared to cells that were DMSO‐treated (control) (Figure 2H,I), and this inhibitory effect was further enhanced by FBXL7 knock‐down (Figure 2H,I), indicating that the loss of FBXL7 loss strengthened the cytotoxicity in glioma cells mediated by of TMZ. The gene discussed is FBXL7; the disease is glioma.