It was observed that age (1.103 [95% CI: 1.077‐1.129], P < .05), sex (2.547 [95% CI: 1.387‐4.676], P < .05), serum ALT ≥ 64 IU/L (11.997 [95% CI: 5.074‐29.665], P < .05), serum AST ≥ 40 IU/L (4.901 [95% CI: 2.204‐10.899], P < .05), AFP ≥ 8.78ng/mL (23.552 [95% CI: 12.275‐45.19], P < .05), NLR ≥ 2.07 (0.424 [95% CI: 0.253‐0.709], P < .001), cirrhosis (19.046 [95% CI: 10.763‐33.705], P < .05), and HBeAg+(2.004 [95% CI: 1.13‐3.554], P < .05), with antiviral (0.407 [95% CI: 0.234‐0.708], P < .001) were significantly correlated with HBV‐HCC (Table 2). This evidence concerns the gene GPT and hepatocellular carcinoma.