This is supported by other reports that long‐term abnormalities in serum levels of ALT are independent predictors for HCC.22, 29, 31 In addition, abnormal serum ALT levels after antiviral therapy are significant risk factor for the development of HCC, while rapidly normalized ALT might minimize the risk of HCC development in patients with HBV‐associated cirrhosis.22, 32 Therefore, sustained antiviral therapy is needed to reduce abnormal serum ALT level and decrease the risk of HBV‐HCC. The gene discussed is GPT; the disease is hepatocellular carcinoma.