Infection with a 200-fold higher dose (1 x 106) was largely similar in terms of survival, although GbpChr3-KO mice were slightly more susceptible to infection by B. thailandensis vgrG5ΔCTD than Gbp2−/− and Gbp5−/− mice, suggesting that at this high dose GBPs may play a small role outside of their function to restrict cell-cell fusion-induced pathology (S6 Fig). The gene discussed is GBP5; the disease is infection.