The results showed that ZIKV infection of hNPC at an MOI (0.1 or 1) led to transcriptional and translational up-regulation of C19orf66 by 34.99±5.80 or 68.01±1.49 fold respectively compared with the levels in the control group (Fig 1C and 1D). Here, SHFL is linked to Zika virus infectious disease.