The finding that CRB2S is expressed elsewhere in the CNS suggests it may operate more widely to promote local delamination: future studies are needed to establish whether its expression in SVL cells of the lateral ventricle, a recognised stem cell niche in the brain, promotes delamination associated with neuronal differentiation, and whether its expression in the eye is involved in dynamism of the retinal neuroepithelium, where loss of CRB2 leads to retinal degeneration [41,66,68,81,82]. Here, CRB2 is linked to retinal degeneration.