Blocking of mDia2 in fibroblasts may well have a similar effect, but prolonged exposure to SMIFH2 leads to p53 downregulation (Isogai et al, 2015b), and reports showing that downregulation of mDia2 in certain cancer cells promotes their motility have to be considered and may limit the usefulness of mDia2 inhibitors (Di Vizio et al, 2009; Creekmore et al, 2011; Pettee et al, 2014). This evidence concerns the gene DIAPH3 and cancer.