The serum CRP level is related to the activity of tumors because specific antigens on the surface of tumor cells can induce the anti-tumor immune response, and tumor cells also produce inflammatory proteins to promote the secretion of CRP.[31–33] Low-serum albumin level indicating that the body is in a state of malnutrition, which has been shown to be associated with poor outcomes in gastric cancer.[34,35] Gastric cancer often causes difficulty in eating and/or digestive dysfunction, so the proportions of malnutrition and cachexia in patients with gastric cancer are comparatively high. This evidence concerns the gene CRP and gastric cancer.