Previous studies demonstrated that the blockage of NF‐κB activation by specific NF‐κB inhibitors suppressed the expression of tumour progression‐associated proteins (XIAP, MMP‐2, MMP‐9, VEGF and Cyclin D1) and reduced cell invasion in glioblastoma.27, 29 Here, we found that imipramine may effectively reduce the protein levels of MGMT and NF‐κB activation in glioblastoma (Figures 6A‐D and 8D). This evidence concerns the gene MMP2 and neoplasm.