Long‐term use of tricyclic antidepressants (TCAs) has been indicated to decrease glioma risk.21 Imipramine, the TCA, has been shown to induce an accumulation of reactive oxygen species and inhibits NF‐κB p65 gene expression in glioblastoma.22 Jeon et al23 presented imipramine‐inhibited tumour cell growth through autophagy in glioblastoma in vitro. The gene discussed is NFKB1; the disease is glioblastoma.