NFKB1 and glioblastoma: As compared to various antidepressant drug, such as duloxetine, fluoxetine and mirtazapine, the BBB penetration ability of imipramine was relatively better.24 However, whether the induction of apoptosis and suppression of NF‐κB signalling are associated with the imipramine‐inhibited progression of glioblastomas is ambiguous.