Previous studies have indicated that CRC progression is mediated by the dysregulation of many signaling pathways, including Wnt [19], PI3K/Akt [20,21], Hedgehog [22], ErbB [23], RHOA [24], Notch [25], BMP [26], Hippo [27], AMPK [28], NF-κB [29], MAPK [3] and JNK [30]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.