The formation, development and progression of CRC is mediated by the dysregulation of multiple signaling pathways, including Wnt [19], PI3K/Akt [20,21], HH [22], ErbB [23], RHOA [24], Notch [25], BMP [26], Hippo [27], AMPK [28], NF-κB [29], MAPK [3] and JNK [30]. Here, MAPK8 is linked to colorectal carcinoma.