PTH and hypertensive disorder: Although many studies had shown that high blood pressure is associated with increased loss of calcium in the urine, leading to a negative calcium balance of bone remodeling and increased levels of parathyroid hormone, which accelerate bone turnover and decrease bone mass [27, 28], recent studies had shown that hypertensive subjects had an increased levels of ghrelin [29, 30], which affect bone directly by inhibiting bone resorption and enhancing bone formation [31].