The highest M-CSF levels were observed in AOSD patients carrying the TT genotype (n = 10; median: 20.28 pg/mL; IQR 16.78-33.86 pg/mL) compared with the carriers of AA genotype (n = 55; median: 6.82 pg/mL; IQR 5.88-10.79 pg/mL) (nonparametric Mann-Whitney U test, P < 0.0001) and AT genotype (n = 17; median: 11.61 pg/mL, IQR 8.47-19.98 pg/mL) (P = 0.027), respectively (Figure 3(c)). The gene discussed is CSF1; the disease is adult-onset Still disease.