We had previously looked for IgM and IgG antibodies on the membranes of various bone marrow cells of ICUS patients using the BMMNC-Coombs test, FCM, and immunofluorescence analysis and determined that some patients had autoantibodies that led to immune dysfunction resulting in the destruction of hematopoietic cells in the bone marrow, causing IRH [13–15]. The gene discussed is CD40LG; the disease is immune system disorder.