Auricchio [25] showed in his study that in the model, assessing the risk of developing atrophic villi in 9-year observation of patients with potential CD, only genetic factors not related to HLA, like SNP in IL12A, OLIG3/TNFAIP3, and IL2/IL21, were significantly connected with the risk of classical CD. Here, IL2 is linked to Cowden disease.