It has been shown that tau phosphorylation is significantly increased in animal models of T2DM, where there is impairment in AMPK [128] and previous studies suggested that this increased tau phosphorylation could be related to inhibition of PP2A, decreased SIRT 1 activity, and overactivity of GSK3β [92, 104, 129, 130]. This evidence concerns the gene PRKAA1 and type 2 diabetes mellitus.