SIRT1 and tauopathy: For instance, as extensively reviewed by Ahmed et al. and Gomes et al., resveratrol prevents oxidative stress and neuroinflammation by activating SIRT1, inhibits the tauopathy by interfering with the midline 1-protein phosphatase 2A complex, improves learning and long-term memory formation by enhancing BDNF expression, and prevents the neuronal cell death by attenuating apoptosis via Akt/p38 MAPK signaling, to mention among the many other mechanisms [222, 223].