CXCL8 and myocardial ischemia: Many studies have demonstrated that inflammation and inflammatory factors play important roles in the pathophysiological mechanism underlying myocardial ischemia-reperfusion injuries, and increased expression levels of IL-1β, IL-6, IL-8, TNF-α, interferon-gamma, and intercellular adhesion molecule-1 have been observed in myocardial tissue [29].