STAT3 and neoplasm: Macrophages secrete a variety of cytokines and cytotoxic mediators, including activator of transcription 3 (STAT3), colony-stimulating factor receptors (CSF-1), ROS, and MMP [67], which promote not only abnormal proliferation and apoptosis of early cells but also the formation and development of tumors and accelerate the infiltration and metastasis of tumor cells [68].