CCL2 and lung carcinoma: As a radiosensitizer of lung cancer, β-elemene effectively controls radiation- and hypoxia-induced activation of the Prx-1/NF-κB/HIF-1α pathway, inhibiting the expression of monocyte chemoattractant protein 1 (MCP-1) and the infiltration and polarization of M2 macrophages induced by radiation in vivo, which reduces the damage and improves the inflammatory environment of tumors [130].