Recent studies indicated that Apelin participates in autophagy process which contributes to antiaging: Apelin 13 induces autophagy and reduces the accumulation of lipid in foam cells [17], Apelin 13 significantly increases expression of LC3-II/I and beclin-1 in H9c2 cardiomyocytes [18], and Apelin increases the viability of arterial disease-mesenchymal stem cells by promoting protective autophagy [19]. This evidence concerns the gene BECN1 and arterial disorder.