We found that patients with pure GGNs, CEA ≤ 4.5 ng/ml, SUVmax < 2.5, or a maximum tumor diameter of ≤1 cm, whose intraoperative frozen section was confirmed as AIS/MIA/LPA, or whose N1 lymph nodes frozen sections were negative had a low probability of iLSN metastasis and, thus, may be suitable for segmentectomy. Here, CEACAM5 is linked to neoplasm.