Therefore, patients without N1 lymph node metastasis (P=0.036), with AIS/MIA/LPA (P=0.038), SUVmax < 2.5 (P=0.029), serum CEA levels ≤4.5 ng/ml (P=0.036), purely GGN lesions (P=0.025), or a maximum tumor diameter of ≤1 cm (P=0.017) had significantly lower iLSN metastasis rates than those without these characteristics. The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.