PDRN also improved gastric ulcer healing by suppressing inflammatory cytokines, such as TNF-α, IL-1β, and IL-6 through A2AR. In addition, the present study additionally observed a relationship between DMPX, a specific adenosine A2A receptor antagonist, and PDRN in a model of ischemic colitis. This evidence concerns the gene ADORA2A and gastric ulcer.