PDK1 and cancer: Although there were also studies to confirm the roles of Gli2 (Glioma-associated oncogene family member 2) [57], PDK1 (pyruvate dehydrogenase kinase) [58], NDUFAF1 (NADH dehydrogenase 1 alpha subcomplex assembly factor 1) [59], SLAMF7 (SLAM family member 7) [60], and CH25H (cholesterol 25-hydroxylase) [61], their conclusions seemed to be opposite with our study, which may be attributed to the differences in cancer type or sample size and thus further validation experiments are needed.