No clear evidences in its involvement in blend pedigrees are known.<h4>Conclusion</h4>This evidence supports the involvement of <i>ETV6</i> in the predisposition to both solid and hematologic neoplasia and the importance of the investigation of the noncoding regions of the genes as recently suggested by different expert groups.<i>ETV6</i> was associated with hematologic malignancies, in particular myeloid malignancies, and recently described as mutated also in oncologic patients. Here, ETV6 is linked to hematologic disorder.