The negative findings on common LRRK2 PD causing mutations, and the presence of LRRK2 Asian-specific variants in our PD patients, although at insignificant level compared with controls, suggest that further large-cohort genetic studies are required in Central Asia to ascertain the pathogenicity of LRRK2 Asian-specific variants in the Central Asian PD population. Here, LRRK2 is linked to Parkinson disease.