As for CHD subjects, results conveyed elevated levels of inflammation, manifested as higher levels of CRP, IL-6, and plasma vascular endothelial cell growth factor (VEGF), in CHD patients with depression under the condition of hypothalamic-pituitary-adrenocortical (HPA) axis hypoactivity and activation of the kynurenine pathway [112]. This evidence concerns the gene IL6 and depressive disorder.