So we did an analysis of the transcription regulatory network; our results indicated five transcription factors could upregulate the SEZ6L2 gene, namely, GCNF, E47, MYOD, ZIC3, and FREAC3; no evidence shows that STAT3 can regulate the expression of SEZ6L2 in HCC. The gene discussed is FOXC1; the disease is hepatocellular carcinoma.