High SEZ6L2 protein expression levels were significantly correlated with tumor-node-metastasis stages (P = 0.046), tumor number (P = 0.016), and tumor size (P = 0.029), while there was no significant correlation with gender (P = 0.186), age (P = 0.612), or AFP (P = 0.984). Here, SEZ6L2 is linked to neoplasm.