PPARGC1A and Parkinson disease: In another rat model of Parkinson's disease, fucoidan from Laminaria japonica alleviated Parkinson's disease-like behaviors, reduced nigral dopaminergic neuronal loss and oxidative stress, prevented the reduction on dopamine and its metabolites, and enhanced mitochondrial respiratory function through the peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α)/Nrf2 pathway in rotenone-induced rats [211].