In rat model of Alzheimer's disease, extract of Panax ginseng has been reported to enhance learning and memory ability, reduce oxidative damage, and inhibit the receptors for advanced glycation end product (RAGE) and NF-κB expressions in the cortex and hippocampus of advanced glycation end product- (AGE-) induced rats [155]. This evidence concerns the gene NFKB1 and early-onset autosomal dominant Alzheimer disease.