AKT1 and Parkinson disease: In another model of Parkinson's disease, Uncaria rhynchophylla has been reported to increase cell viability, attenuate dopaminergic neuronal loss of substantia nigra and striatum, inhibit heat-shock protein 90 and apoptosis, and thereby induce autophagy through MAPKs and PI3K-serine/threonine protein kinase (Akt) pathways in MPP+-induced SH-SY5Y cells and MPTP-induced mouse model [186].