lactis BB-12 (5 × 107 CFU of single probiotic strain/day or 2.5 × 107 CFU each strain/day) and germinated brown rice extract (GBR; 10% in diet) for 10 weeks reduced the mucin-depleted foci formation, ACF-producing sialomucin and expression of anti-apoptotic Bcl-2 in azoxymethane/dextran sodium sulfate-induced CRC rat model. The gene discussed is BCL2; the disease is colorectal carcinoma.