In preclinical development, treatment of murine breast cancer xenografts with a different monoclonal antibody that blocks GAS6 binding, YW327.6S2, that binds both human and murine AXL, decreased tumor growth, inhibited the activity of tumor-associated macrophages, and decreased metastasis formation from MDA-MB-231 xenografts [125]. This evidence concerns the gene AXL and breast cancer.