AKT1 and breast cancer: In breast cancer, AXL can stimulate a variety of downstream pathways, including phosphatidylinositide 3-kinase/RAC-α serine/threonine protein kinase (PI3K/AKT), extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and the NF-κB pathway, as well as signal transducer and activator of transcription signaling (STAT) pathways [34].