A2M and diabetic retinopathy: In fact, high-throughput sequencing indicated that the coexpressed gene, A2M (A2MD|CPAMD5|FWP007|S863-7) which encodes the α-2-macroglobulin that acts as a carrier of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α [27], causes diabetic retinopathy [28].