For instance, PD-L1 expression profiling may predict the response of anti-PD-L1 therapy [12], and we have demonstrated that the primary tumor and tumor thrombus have differing PD-L1 expression and that a biopsy of the primary tumor in the kidney is unlikely to predict the PD-L1 expression profile of the tumor thrombus [13]. This evidence concerns the gene CD274 and neoplasm.