Finally, we evaluated the prognostic value of 9 hub genes by using GEPIA database and found ACC patients with high expression of 9 hub genes (CCNB1, CDK1, TOP2A, CCNA2, CDKN3, MAD2L1, RACGAP1, BUB1 and CCNB2) were significantly associated with worse OS. This evidence concerns the gene TOP2A and adrenal cortex carcinoma.