However, somatic mutations in PTEN gene have found to be infrequent in melanomas (reviewed in Aguissa‐Touré and Li, 2012); hence, alternative molecular mechanisms such as SCNAs and promoter hypermethylation have been proposed as an alternative mechanism of blocking PTEN functions (Roh et al., 2016; Stahl et al., 2003). This evidence concerns the gene PTEN and melanoma.