TP53 and adrenal cortex carcinoma: It is important to note that in a smaller paediatric ACC cohort (N = 21, The Hospital for Sick Children, Canada) of TP53 mutation carriers with more penetrant mutations and diagnosed at ages ranging from 1 to 17.83 years (Supplementary Table 3), no significant difference in ACC age-of-onset with the rs971074 SNP genotype was observed (Supplementary Table 4).