IKBKE and systemic lupus erythematosus: As shown in Fig. 2, we revealed that the median expression levels of IKBKE mRNA in SLE patients (Q50 = 0.013 (Q25 = 0.009, Q75 = 0.015)) were lower than those in healthy controls (0.025 (0.014, 0.023)), with 1.92-fold increase in healthy controls compared with SLE patients (P = 2.32 × 10−12).