Evidence showed that compared with placebo, testosterone supplementation did not i) increase total BMD, vertebral, hip and femoral BMD; ii) decrease the risk of falling or fracture; or iii) increase the risk of cardiovascular events, all-cause mortality or prostatic events, such as PSA increase or prostatitis; however, testosterone supplementation was associated with improved quality of life and sexual function. This evidence concerns the gene KLK3 and medical procedure.