Diabetes + STD showed an increased intensity of immunohistochemical staining for phospho-S6 ribosomal protein (p-S6RP) (a downstream effector molecule of mTORC1) in tubular lesions compared to that in the control rats, and LPD decreased the intensity of its staining to levels similar to those observed in the controls (Figure 5A and 5B). Here, RPS6 is linked to diabetes mellitus.