Several studies have assessed the functional role of FN1 in melanoma cells in vitro and the role of niche and plasma fibronectin in the context of melanoma metastasis (von Au et al., 2013; Garmy‐Susini et al., 2010; Malik et al., 2010; Pasqualini, Bourdoulous, Koivunen, Woods, & Ruoslahti, 1996), but we reveal a new role for melanoma cell‐derived FN1, which due to cooperative effects accelerates the growth of heterogeneous tumours and enhances melanoma cell dissemination by acting on CTCs. This evidence concerns the gene FN1 and neoplasm.