In addition to unequivocal evidence of SOD1 misfolding and aggregation in SOD1‐linked familial ALS,[90] post‐mortem analyses of sporadic ALS,[90b] non‐SOD1‐linked familial ALS,[90c] Parkinson's disease[13] and Alzheimer's disease[91] patient tissues suggest SOD1 misfolding may constitute a shared pathological feature amongst numerous neurodegenerative diseases. This evidence concerns the gene SOD1 and early-onset autosomal dominant Alzheimer disease.