In agreement, a recent investigation by Wang and colleagues[100] applied a recalibrated Chiti‐Dobson equation to the most extensive set of patient data and mutant biophysical measurements to date, and found that 69 % of variability in the survival time of SOD1‐linked familial ALS patients could be accounted for by integrating the effects of SOD1 mutations on aggregation rate and protein stability. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.