MAPK7 and Familial prostate cancer: Furthermore, pharmacological inhibition of ERK5 suppressed cell migration and invasion in some types of cancer cells in vitro (Sawhney et al., 2009; Rovida et al., 2015), and it reduced metastasis of liver and prostate cancer xenografts in vivo (Ramsay et al., 2011; Rovida et al., 2015).