MAPK7 and hepatocellular carcinoma: For example, in meningiomas IOMM-Lee cells, ERK5 may be involved in HER-2-mediated migration and invasion (Wang et al., 2016); in OVCAR-3 ovarian cancer cells, ERK5 promotes the expression of type II collagen, thereby promoting tumor cell invasion and migration (Dai et al., 2015); in Huh-7 and HepG2 HCC cells, ERK5 mediates EGF or hypoxia-driven migration and invasion (Rovida et al., 2015).