The p53 mutant mice exhibited a similar tumor profile as ESC-based p53 KO mice reported previously17,18; however, the brain tumors that were previously observed only in heterozygotes of ESC-based p53 KO mice were observed in our homozygous p53 mutant mice (2 out of 21 mice with tumor) (Supplementary Table 5). The gene discussed is TP53; the disease is neoplasm.