Interestingly, unlike mammalian cells where the Arf GEF and GAP families contain up to 15 and 27 members respectively14, the P. falciparum genome encodes two putative ArfGAP proteins and a single Sec7 domain-containing putative ArfGEF, responsible for the BFA sensitivity of malaria parasites34,35. This evidence concerns the gene CYTH1 and malaria.